Question:
Tolerance in opioids develops to all except?
Tolerance in opioids develops to all except?
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Tolerance does not develop to two opioid effects: constipation and one pupil sign.
Updated On: Jun 24, 2026
- Miosis
- Analgesia
- Euphoria
- Nausea and vomiting
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The Correct Option is A
Solution and Explanation
Step 1: Recall that with chronic opioid use, tolerance develops to most pharmacological effects, but a few effects do NOT show tolerance.
Step 2: Tolerance does develop to analgesia, euphoria, respiratory depression, sedation, and to the emetic (nausea and vomiting) effect over time. So options B, C and D are all effects to which tolerance develops.
Step 3: The two classic effects to which tolerance does NOT develop are miosis (pupillary constriction) and constipation. These persist throughout chronic use, which is why pinpoint pupils remain a reliable sign in chronic opioid users and overdose.
Step 4: Since tolerance does not develop to miosis, option A is the exception and is the correct answer.
Step 2: Tolerance does develop to analgesia, euphoria, respiratory depression, sedation, and to the emetic (nausea and vomiting) effect over time. So options B, C and D are all effects to which tolerance develops.
Step 3: The two classic effects to which tolerance does NOT develop are miosis (pupillary constriction) and constipation. These persist throughout chronic use, which is why pinpoint pupils remain a reliable sign in chronic opioid users and overdose.
Step 4: Since tolerance does not develop to miosis, option A is the exception and is the correct answer.
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