Question:
Thiazide diuretics act on which part of the nephron?
Thiazide diuretics act on which part of the nephron?
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Thiazides block the Na-Cl symporter in the early distal tubule.
Updated On: Jun 24, 2026
- Proximal convoluted tubule (PCT)
- Distal convoluted tubule (DCT)
- Glomerulus
- Descending limb of the loop of Henle
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The Correct Option is B
Solution and Explanation
Step 1: Diuretics are classified by their tubular site of action. Carbonic anhydrase inhibitors act in the PCT, loop diuretics in the thick ascending limb, thiazides in the cortical diluting segment and early distal tubule, and potassium-sparing diuretics in the late distal tubule and collecting duct.
Step 2: Thiazides inhibit the Na-Cl symporter in the early distal convoluted tubule (the cortical diluting segment). This blocks sodium and chloride reabsorption there, producing a moderate diuresis. So option (b) DCT is correct.
Step 3: The glomerulus (c) is a filtration site, not a target for thiazides. The descending limb of the loop of Henle (d) is permeable to water but does not actively reabsorb the salt that thiazides block, so it is wrong. The PCT (a) is the site for acetazolamide, not thiazides.
Step 2: Thiazides inhibit the Na-Cl symporter in the early distal convoluted tubule (the cortical diluting segment). This blocks sodium and chloride reabsorption there, producing a moderate diuresis. So option (b) DCT is correct.
Step 3: The glomerulus (c) is a filtration site, not a target for thiazides. The descending limb of the loop of Henle (d) is permeable to water but does not actively reabsorb the salt that thiazides block, so it is wrong. The PCT (a) is the site for acetazolamide, not thiazides.
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