Operate $R_2 - R_1; R_3 - R_1$ we get the determinant as
$\begin{vmatrix}x+1 &x+2&x+4\\ 2& 3 &4 \\ 6 &8 &10\end{vmatrix} $ operate
$C_3 - C_2; C_2 - C_1$, we get the value
= $\begin{vmatrix}x+1 &1&3\\ 2& 1 &2 \\ 6 &2 &4\end{vmatrix} $ operate $R_3 - 2 \,R_2$, we get
$\begin{vmatrix}x+1 &1&3\\ 2& 1 &2 \\ 2 &0 &0\end{vmatrix} = 2 \begin{vmatrix}1&3\\ 1&2\end{vmatrix} = 2 ( 2 - 3) = - 2$