Step 1: Recall the shear flow relation.
The shear flow expression
\[
\boxed{
q=\frac{VQ}{I}
}
\]
is derived for thin-walled sections.
It assumes that the shear stress is nearly uniform through the wall thickness.
Step 2: Identify why it fails for thick sections.
In thick-walled members, the shear stress varies significantly across the thickness.
Therefore, the thin-wall assumption is no longer valid.
Hence,
\[
\boxed{
\text{The shear stress is no longer uniform across the thickness of the section.}
}
\]
Thus,
\[
\boxed{(C)}
\]
is the correct answer.