Question

The peptidyl transferase enzyme activity is located in the

• A. Variable loop of tRNA
• B. Large ribosomal subunit
• C. Acceptor arm of tRNA
• D. Small ribosomal subunit

Hint:

Understand the role of ribosomal subunits and rRNA in catalyzing peptide bond formation.

Answer 1

The Correct Option is B

Peptidyl transferase is the enzyme responsible for catalyzing the peptide bond formation during protein synthesis. This activity is intrinsic to the rRNA component of the large ribosomal subunit (50S in prokaryotes and 60S in eukaryotes). The small ribosomal subunit is mainly involved in decoding mRNA, while tRNA components (variable loop and acceptor arm) are critical for amino acid recognition and attachment but do not possess enzymatic activity.