Question:
The graph below shows the dose-response curves of three drugs A, B and C. Which of the following drugs shown in the graph has the highest potency?
The graph below shows the dose-response curves of three drugs A, B and C. Which of the following drugs shown in the graph has the highest potency?
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Potency is about how far left the curve sits, not how high it rises.
Updated On: Jun 23, 2026
- Drug A
- Drug B
- Drug C
- Both Drug A & B
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The Correct Option is A
Solution and Explanation
Step 1: Potency is defined by the position of the dose-response curve (DRC) along the dose axis. It is the amount of drug needed to produce a given effect, measured as the EC50 (dose giving a half-maximal response).
Step 2: The more a curve sits to the left, the lower its EC50, meaning less drug is needed for the same effect, so the higher its potency. A rightward DRC means lower potency.
Step 3: In the graph, Drug A's curve is the leftmost (lowest EC50), so Drug A is the most potent. Curve position, not the maximal height (efficacy), is what defines potency.
Answer: Drug A.
Ref: K. D. Tripathi, 7e, p 54-55.
Step 2: The more a curve sits to the left, the lower its EC50, meaning less drug is needed for the same effect, so the higher its potency. A rightward DRC means lower potency.
Step 3: In the graph, Drug A's curve is the leftmost (lowest EC50), so Drug A is the most potent. Curve position, not the maximal height (efficacy), is what defines potency.
Answer: Drug A.
Ref: K. D. Tripathi, 7e, p 54-55.
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