Question:
The first evidence of ‘gene transfer’ was demonstrated in 1928 by
The first evidence of ‘gene transfer’ was demonstrated in 1928 by
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Griffith → Transformation (1928); Avery–MacLeod–McCarty → DNA as genetic material (1944).
Updated On: Sep 8, 2025
- Joshua Lederberg in Escherichia coli
- Frederick Griffith in Streptococcus pneumoniae
- Joshua Lederberg in bacteriophages
- Alexander Fleming in Penicillium notetum
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The Correct Option is B
Solution and Explanation
Step 1: Griffith’s experiment (1928).
Griffith performed experiments with virulent (smooth, S-type) and non-virulent (rough, R-type) strains of Streptococcus pneumoniae.
Step 2: Key observation.
When heat-killed S strain was mixed with live R strain, the R strain transformed into a virulent form. This provided the first evidence of “gene transfer” through transformation.
Step 3: Later confirmation.
Avery, MacLeod, and McCarty (1944) later confirmed DNA as the genetic material responsible for this transformation.
Final Answer: \[ \boxed{\text{Frederick Griffith in Streptococcus pneumoniae (1928).}} \]
Griffith performed experiments with virulent (smooth, S-type) and non-virulent (rough, R-type) strains of Streptococcus pneumoniae.
Step 2: Key observation.
When heat-killed S strain was mixed with live R strain, the R strain transformed into a virulent form. This provided the first evidence of “gene transfer” through transformation.
Step 3: Later confirmation.
Avery, MacLeod, and McCarty (1944) later confirmed DNA as the genetic material responsible for this transformation.
Final Answer: \[ \boxed{\text{Frederick Griffith in Streptococcus pneumoniae (1928).}} \]
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