Question

The drug of choice in Paracetamol overdose is:

• A. N-acetylcysteine
• B. Dopamine
• C. Hydralazine
• D. Furosemide

Hint:

Early administration of N-acetylcysteine in paracetamol overdose is crucial to preventing liver damage.

Answer 1

The Correct Option is A

The question asks for the drug of choice in the case of a Paracetamol overdose. Let's analyze the options provided:

1. N-acetylcysteine: This is the correct choice. N-acetylcysteine (NAC) is an antidote used for treating acute Paracetamol (acetaminophen) overdose. NAC acts by replenishing the levels of glutathione in the liver. Glutathione helps to conjugate the reactive metabolite NAPQI, which is formed when Paracetamol is metabolized and can cause liver damage.
2. Dopamine: This is primarily used as a medication to treat low blood pressure, heart failure, or improving blood flow to specific organs. It is not used for Paracetamol overdose.
3. Hydralazine: This is an antihypertensive medication used to treat high blood pressure. It does not play a role in Paracetamol overdose treatment.
4. Furosemide: This is a diuretic, often used to treat fluid build-up, such as in congestive heart failure. It is not related to the treatment of Paracetamol overdose.

In summary, N-acetylcysteine is used because it counteracts the toxic effects of Paracetamol by protecting the liver. None of the other options serve this function in the context of a Paracetamol overdose.

Conclusion: The drug of choice in Paracetamol overdose is N-acetylcysteine.