Question

The development of chondrosarcoma is related with?

• A. Maffucci syndrome
• B. Felty syndrome
• C. Both a and b
• D. None of the above

Hint:

Multiple enchondromas with haemangiomas carry a high malignant change risk; Felty is an RA triad.

Answer 1

The Correct Option is A

Step 1: Chondrosarcoma arising in a pre-existing benign cartilage lesion is called secondary chondrosarcoma. Its main precursors are osteochondroma and enchondroma.

Step 2: Maffucci syndrome (multiple enchondromas plus soft tissue haemangiomas) and Ollier disease (multiple enchondromatosis) both carry a high risk of malignant change, roughly a 25-30% lifetime risk of developing chondrosarcoma.

Step 3: Compare this with the small 2% risk in a solitary osteochondroma and 5-25% in multiple hereditary osteochondromatosis. So Maffucci syndrome is strongly linked to chondrosarcoma.

Step 4: Felty syndrome is the triad of rheumatoid arthritis, splenomegaly and neutropenia, and has nothing to do with cartilage tumours. Hence the answer is Maffucci syndrome alone.