Step 1: Understanding the cofactor.
The cofactor of an element \( a_{ij} \) in a matrix is given by:
\[
C_{ij} = (-1)^{i+j} \times \text{determinant of the minor of } a_{ij}
\]
where the minor of \( a_{ij} \) is the determinant of the submatrix obtained by deleting the \( i \)-th row and the \( j \)-th column from the original matrix.
We are asked to find the cofactor of the element \( a_{21} \), which is the element in the second row and first column of the matrix.
Step 2: Remove the second row and first column to get the minor.
To find the minor of \( a_{21} \), we remove the second row and first column of the matrix:
\[
\text{Minor of } a_{21} = \begin{vmatrix} 4 & 4 1 & 2 \end{vmatrix}
\]
Step 3: Calculate the determinant of the minor.
Now calculate the determinant of the 2x2 minor matrix:
\[
\text{determinant of minor} = (4 \times 2) - (4 \times 1) = 8 - 4 = 4
\]
Step 4: Calculate the cofactor.
The cofactor is:
\[
C_{21} = (-1)^{2+1} \times 4 = (-1)^3 \times 4 = -4
\]
Step 5: Conclusion.
Thus, the cofactor of \( a_{21} \) is \( -4 \), and the correct answer is option (C).