Question

The adult dose of Nimesulide is 100mg. What is the dose for a child weighing 12Lbs as per Clark’s formula?

• A. 8mg
• B. 16mg
• C. 10mg
• D. 50mg

Hint:

When calculating pediatric doses, Clark’s formula helps to adjust the adult dose according to the child’s weight, ensuring safe and appropriate medication.

Answer 1

The Correct Option is A

Step 1: Understand Clark’s formula.
Clark’s formula is used to calculate the pediatric dose based on the child’s weight. The formula is: \[ \text{Child's Dose} = \frac{\text{Weight of child (lbs)}}{150} \times \text{Adult Dose} \] Step 2: Apply Clark’s formula.
The adult dose is 100mg, and the child's weight is 12Lbs. Plugging these values into the formula: \[ \text{Child's Dose} = \frac{12}{150} \times 100 = 8 \, \text{mg} \] Step 3: Conclusion.
The correct dose for a child weighing 12Lbs is 8mg. Thus, the correct answer is (1) 8mg.

Answer 2

This is a Clark's-rule dosage problem, so instead of only plugging numbers into the formula, let's check each option by working backwards from Clark's rule and seeing which one is dimensionally consistent with a 12 lb child and a 100 mg adult dose.

1. 8mg: Clark's rule states child's dose = (child's weight in lb ÷ average adult weight of 150 lb) × adult dose. For a 12 lb child, this fraction is \( \frac{12}{150} \), which is close to \( \frac{1}{12.5} \) of the adult dose. One-twelfth of 100 mg is approximately 8 mg, so this option is dimensionally consistent with the rule.
2. 16mg: This would require the weight fraction \( \frac{16}{100} = 0.16 \), i.e. \( \frac{x}{150} = 0.16 \), giving a child's weight of about 24 lb - double the actual 12 lb given in the question, so this option overestimates the dose.
3. 10mg: This corresponds to a weight fraction of 0.10, i.e. a child's weight of 15 lb, which is close to but still higher than the actual 12 lb, so this value is not the exact result of the formula.
4. 50mg: This would need a weight fraction of 0.50, i.e. a child's weight of 75 lb - nowhere close to 12 lb, so this option is far too high and can be ruled out immediately.

Only the 8 mg option is numerically consistent with a 12 lb child and a 150 lb reference adult weight in Clark's rule.

Therefore, the correct answer is 8mg.