Question:
Streptokinase and urokinase are contraindicated in:
Streptokinase and urokinase are contraindicated in:
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Clot busters risk fatal bleeding; which option sits inside the skull?
Updated On: Jun 24, 2026
- Intracranial malignancy
- Pulmonary embolism
- Arteriovenous fistula
- Thrombophlebitis
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The Correct Option is A
Solution and Explanation
Step 1: Streptokinase and urokinase are fibrinolytic (clot dissolving) drugs. The concept tested is when these drugs must NOT be used because they cause dangerous bleeding.
Step 2: The main absolute contraindications to fibrinolytics are conditions with a high bleeding risk, especially in the brain. These include intracranial tumor, recent intracranial or spinal surgery, recent stroke, active internal bleeding, and aortic dissection.
Step 3: An intracranial malignancy carries a very high risk of catastrophic intracranial hemorrhage if a clot-dissolving drug is given. So it is an absolute contraindication and option A is correct.
Step 4: Why the others are wrong. Pulmonary embolism is in fact an indication for thrombolysis, not a contraindication (option B wrong). An arteriovenous fistula is not an absolute contraindication to these drugs (option C wrong). Thrombophlebitis is not a contraindication; thrombotic conditions are usually treated, not avoided (option D wrong).
Step 5: The bleeding danger inside the skull makes intracranial malignancy the answer.
Answer: A. Intracranial malignancy.
Step 2: The main absolute contraindications to fibrinolytics are conditions with a high bleeding risk, especially in the brain. These include intracranial tumor, recent intracranial or spinal surgery, recent stroke, active internal bleeding, and aortic dissection.
Step 3: An intracranial malignancy carries a very high risk of catastrophic intracranial hemorrhage if a clot-dissolving drug is given. So it is an absolute contraindication and option A is correct.
Step 4: Why the others are wrong. Pulmonary embolism is in fact an indication for thrombolysis, not a contraindication (option B wrong). An arteriovenous fistula is not an absolute contraindication to these drugs (option C wrong). Thrombophlebitis is not a contraindication; thrombotic conditions are usually treated, not avoided (option D wrong).
Step 5: The bleeding danger inside the skull makes intracranial malignancy the answer.
Answer: A. Intracranial malignancy.
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