Question:
Sacubitril is a:
Sacubitril is a:
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It is the neprilysin-blocking half of the valsartan combination used in heart failure.
Updated On: Jun 24, 2026
- ACE inhibitor
- Neutral endopeptidase inhibitor
- Calcium channel inhibitor
- Beta adrenergic blocker
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The Correct Option is B
Solution and Explanation
Step 1: Identify the drug. Sacubitril is a prodrug whose active metabolite inhibits neprilysin, also called neutral endopeptidase.
Step 2: Understand the action. Inhibiting neprilysin prevents breakdown of natriuretic peptides, enhancing vasodilation and natriuresis.
Step 3: Conclude. Sacubitril is a neutral endopeptidase (neprilysin) inhibitor, so option B is correct. It is combined with valsartan in a 1:1 ratio (an ARNI) for heart failure.
Step 4: Exclude distractors. It is not an ACE inhibitor, calcium channel blocker, or beta blocker; those act by entirely different mechanisms.
Step 2: Understand the action. Inhibiting neprilysin prevents breakdown of natriuretic peptides, enhancing vasodilation and natriuresis.
Step 3: Conclude. Sacubitril is a neutral endopeptidase (neprilysin) inhibitor, so option B is correct. It is combined with valsartan in a 1:1 ratio (an ARNI) for heart failure.
Step 4: Exclude distractors. It is not an ACE inhibitor, calcium channel blocker, or beta blocker; those act by entirely different mechanisms.
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