Question

Posterior lenticonus is seen in?

• A. Alport's syndrome
• B. Lowe's syndrome
• C. Marfan syndrome
• D. Homocystinuria

Hint:

Anterior lenticonus goes with Alport, posterior lenticonus goes with Lowe.

Answer 1

The Correct Option is B

Step 1: Lenticonus is a cone-shaped bulging of the lens surface. When the anterior pole bulges it is anterior lenticonus, and when the posterior pole bulges it is posterior lenticonus.

Step 2: Anterior lenticonus is the classic ocular sign of Alport's syndrome. Posterior lenticonus, on the other hand, is associated with Lowe's (oculocerebrorenal) syndrome.

Step 3: Marfan syndrome and homocystinuria cause ectopia lentis (subluxation of the lens), not lenticonus, so they are distractors here.

Step 4: On distant direct ophthalmoscopy lenticonus appears as an oil-droplet in the red reflex, confirmed on slit lamp. Hence posterior lenticonus is seen in Lowe's syndrome.