Question:
Pirenzepine is used in the treatment of:
Pirenzepine is used in the treatment of:
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Think of the selective M1 anticholinergic that cuts gastric acid secretion.
Updated On: Jun 24, 2026
- Gastric ulcer
- Glaucoma
- Hypertension
- Congestive cardiac failure
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The Correct Option is A
Solution and Explanation
Step 1: Identify the drug class. Pirenzepine is a selective \(M_1\) muscarinic receptor antagonist (anticholinergic).
Step 2: Understand its action. By selectively blocking \(M_1\) receptors on the enterochromaffin-like and parietal cell pathways, it reduces gastric acid secretion. It works at a low therapeutic dose range.
Step 3: Apply to the options. Reduced acid secretion makes it useful for peptic and gastric ulcer disease, so option A is correct.
Step 4: Exclude distractors. It is not used for glaucoma (those need pilocarpine or beta blockers), hypertension, or congestive cardiac failure, none of which involve \(M_1\) acid-secretion blockade.
Step 2: Understand its action. By selectively blocking \(M_1\) receptors on the enterochromaffin-like and parietal cell pathways, it reduces gastric acid secretion. It works at a low therapeutic dose range.
Step 3: Apply to the options. Reduced acid secretion makes it useful for peptic and gastric ulcer disease, so option A is correct.
Step 4: Exclude distractors. It is not used for glaucoma (those need pilocarpine or beta blockers), hypertension, or congestive cardiac failure, none of which involve \(M_1\) acid-secretion blockade.
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