Step 1: Understanding the sentence.
The phrase "Fate smiles with those" implies that fate is in favor of those who work hard, implying that the correct preposition is "with" to connect the subject (fate) and those who work tirelessly.
Step 2: Analyzing the options.
(A) with: Correct — The phrase "Fate smiles with those" is grammatically correct.
(B) over: This would be incorrect as it does not fit the context of the sentence.
(C) on: This would be incorrect in the context of the sentence. "On" does not make sense with the verb "smiles" in this case.
(D) round: This is incorrect as "round" doesn't fit the context of fate smiling upon someone.
Step 3: Conclusion.
The correct answer is (A) with, as it makes the sentence grammatically correct.