Question:
Patient presented with proximal tubule proteinuria. Which metal is likely to be associated with it?
Patient presented with proximal tubule proteinuria. Which metal is likely to be associated with it?
Updated On: Jul 14, 2025
- Cadmium
- Mercury
- Gold
- Lead
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The Correct Option is A
Solution and Explanation
Proximal tubule proteinuria indicates damage to the proximal tubules of the kidney, leading to the leakage of proteins that should otherwise be reabsorbed. This condition can be induced by exposure to certain metals, particularly those known to be nephrotoxic. Among the metals listed, cadmium is most commonly associated with renal damage, specifically affecting the proximal tubular cells.
The mechanism of injury involves the accumulation of cadmium in the kidney, where it disrupts cellular functions and leads to proximal tubular cell injury. This results in proteinuria, as the kidney's ability to reabsorb proteins is impaired.
| Metal | Associated Condition |
| Cadmium | Proximal tubule proteinuria |
| Mercury | General nephrotoxicity |
| Gold | Membranous nephropathy |
| Lead | Fanconi syndrome, chronic interstitial nephritis |
Therefore, the metal most likely associated with proximal tubule proteinuria is Cadmium.
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