Question:
Pancreatitis occurs with:
Pancreatitis occurs with:
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Didanosine (ddI): remember its two D-toxicities, the pancreas and the nerves.
Updated On: Jun 24, 2026
- Abacavir
- Zidovudine
- Lamivudine
- Didanosine
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The Correct Option is D
Solution and Explanation
Step 1: All four drugs are nucleoside reverse transcriptase inhibitors (NRTIs) used in HIV treatment, but each has a signature toxicity. The question asks which one classically causes pancreatitis.
Step 2: Didanosine (ddI) is strongly linked with acute pancreatitis and with peripheral neuropathy. Its risk of pancreatitis rises further when combined with other pancreatotoxic agents. So option D is correct.
Step 3: Abacavir is associated with a potentially fatal hypersensitivity reaction tied to the HLA-B*5701 allele, not pancreatitis. So A is wrong.
Step 4: Zidovudine (AZT) is associated with bone marrow suppression, namely anemia and neutropenia, and with myopathy. So B is wrong.
Step 5: Lamivudine (3TC) is one of the best tolerated NRTIs with minimal toxicity. So C is wrong.
Conclusion: Pancreatitis occurs with didanosine, option D.
Step 2: Didanosine (ddI) is strongly linked with acute pancreatitis and with peripheral neuropathy. Its risk of pancreatitis rises further when combined with other pancreatotoxic agents. So option D is correct.
Step 3: Abacavir is associated with a potentially fatal hypersensitivity reaction tied to the HLA-B*5701 allele, not pancreatitis. So A is wrong.
Step 4: Zidovudine (AZT) is associated with bone marrow suppression, namely anemia and neutropenia, and with myopathy. So B is wrong.
Step 5: Lamivudine (3TC) is one of the best tolerated NRTIs with minimal toxicity. So C is wrong.
Conclusion: Pancreatitis occurs with didanosine, option D.
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