Question:
Nitric oxide acts by increasing:
Nitric oxide acts by increasing:
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NO stimulates guanylate cyclase to make which messenger?
Updated On: Jun 24, 2026
- BRCA 1
- BRCA 2
- Interleukin
- cGMP
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The Correct Option is D
Solution and Explanation
Step 1: Nitric oxide (NO) is released from endothelium and diffuses to the surrounding vascular smooth muscle cells.
Step 2: In the smooth muscle, NO activates guanylate cyclase, which increases cyclic guanosine monophosphate (cGMP), a cyclic nucleotide derived from GTP. So option 4 is correct.
Step 3: cGMP acts as a second messenger, much like cyclic AMP, activating intracellular protein kinases that cause smooth muscle relaxation and vasodilation.
Step 4: BRCA1 and BRCA2 are tumor-suppressor genes and interleukins are cytokines; none of them is the second messenger of NO, so options 1, 2, and 3 are wrong.
Step 2: In the smooth muscle, NO activates guanylate cyclase, which increases cyclic guanosine monophosphate (cGMP), a cyclic nucleotide derived from GTP. So option 4 is correct.
Step 3: cGMP acts as a second messenger, much like cyclic AMP, activating intracellular protein kinases that cause smooth muscle relaxation and vasodilation.
Step 4: BRCA1 and BRCA2 are tumor-suppressor genes and interleukins are cytokines; none of them is the second messenger of NO, so options 1, 2, and 3 are wrong.
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