Question:
Niacin therapy is relatively contraindicated in diabetes because it:
Niacin therapy is relatively contraindicated in diabetes because it:
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Niacin worsens glucose tolerance and insulin resistance.
Updated On: Jun 24, 2026
- Increases the blood sugar levels
- Causes scleroderma
- Is difficult to give by injection
- Increases the metabolism of oral hypoglycemic drugs
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The Correct Option is A
Solution and Explanation
Step 1: Recall niacin's metabolic effect. Niacin (nicotinic acid) is a lipid-lowering agent but it impairs glucose tolerance and causes insulin resistance.
Step 2: Link to diabetes. In diabetic patients this worsens glycemic control by raising blood glucose, making it a relative contraindication.
Step 3: Conclude. The reason is that niacin increases blood sugar levels, so option A is correct.
Step 4: Exclude distractors. It does not cause scleroderma, it is given orally, and its concern is hyperglycemia rather than altering hypoglycemic-drug metabolism.
Step 2: Link to diabetes. In diabetic patients this worsens glycemic control by raising blood glucose, making it a relative contraindication.
Step 3: Conclude. The reason is that niacin increases blood sugar levels, so option A is correct.
Step 4: Exclude distractors. It does not cause scleroderma, it is given orally, and its concern is hyperglycemia rather than altering hypoglycemic-drug metabolism.
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