Question:
Necrotizing lymphadenitis is seen in?
Necrotizing lymphadenitis is seen in?
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One of these conditions is literally named histiocytic necrotizing lymphadenitis.
Updated On: Jun 24, 2026
- Kimura disease
- Kikuchi disease
- Hodgkin disease
- Castleman disease
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The Correct Option is B
Solution and Explanation
Step 1: The question asks for the entity whose hallmark histology is necrotizing lymphadenitis.
Step 2: Kikuchi disease (Kikuchi-Fujimoto disease) is also called histiocytic necrotizing lymphadenitis; it characteristically presents in young women with tender cervical lymphadenopathy and fever, and the nodes show patchy paracortical necrosis with abundant histiocytes and karyorrhectic debris but a striking absence of neutrophils.
Step 3: Kimura disease is a chronic allergic/inflammatory condition with eosinophil-rich lymphoid hyperplasia and follicular hyperplasia, not necrotizing lymphadenitis.
Step 4: Hodgkin disease is characterised by Reed-Sternberg cells in an appropriate inflammatory background, not by histiocytic necrotizing lymphadenitis.
Step 5: Castleman disease (angiofollicular lymph node hyperplasia) shows regressed germinal centres with onion-skin mantles and hyalinised vessels, again not necrotizing lymphadenitis.
Conclusion: The correct answer is Kikuchi disease.
Step 2: Kikuchi disease (Kikuchi-Fujimoto disease) is also called histiocytic necrotizing lymphadenitis; it characteristically presents in young women with tender cervical lymphadenopathy and fever, and the nodes show patchy paracortical necrosis with abundant histiocytes and karyorrhectic debris but a striking absence of neutrophils.
Step 3: Kimura disease is a chronic allergic/inflammatory condition with eosinophil-rich lymphoid hyperplasia and follicular hyperplasia, not necrotizing lymphadenitis.
Step 4: Hodgkin disease is characterised by Reed-Sternberg cells in an appropriate inflammatory background, not by histiocytic necrotizing lymphadenitis.
Step 5: Castleman disease (angiofollicular lymph node hyperplasia) shows regressed germinal centres with onion-skin mantles and hyalinised vessels, again not necrotizing lymphadenitis.
Conclusion: The correct answer is Kikuchi disease.
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