Question:
Mycoplasma is intrinsically resistant to which antibiotic?
Mycoplasma is intrinsically resistant to which antibiotic?
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No cell wall means cell-wall-active beta lactams cannot work.
Updated On: Jun 24, 2026
- Ceftriaxone
- Cephalosporins
- Aminoglycosides
- Fluoroquinolones
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The Correct Option is A
Solution and Explanation
Step 1: Recall mycoplasma structure. Mycoplasmas lack a cell wall.
Step 2: Link to drug action. Beta lactams such as ceftriaxone (a third generation cephalosporin) act by inhibiting cell wall synthesis, so with no cell wall to target they are ineffective and mycoplasma is intrinsically resistant.
Step 3: Conclude. Ceftriaxone is the cell-wall-active beta lactam in the options, so option A is correct.
Step 4: Note effective drugs. Macrolides, tetracyclines, and fluoroquinolones, which target protein or DNA, are the first-line treatments for Mycoplasma pneumoniae.
Step 2: Link to drug action. Beta lactams such as ceftriaxone (a third generation cephalosporin) act by inhibiting cell wall synthesis, so with no cell wall to target they are ineffective and mycoplasma is intrinsically resistant.
Step 3: Conclude. Ceftriaxone is the cell-wall-active beta lactam in the options, so option A is correct.
Step 4: Note effective drugs. Macrolides, tetracyclines, and fluoroquinolones, which target protein or DNA, are the first-line treatments for Mycoplasma pneumoniae.
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