| Group I | Group II |
| P) Treponema pallidum | 1) Sleeping sickness |
| Q) Trypanosoma cruzi | 2) Whooping cough |
| R) Trypanosoma gambiense | 3) Chagas disease |
| S) Bordetella pertussis | 4) Syphilis |
To solve this question, we need to correctly match the microorganisms listed in Group I with the diseases listed in Group II.
Based on the above analysis, the correct matches are:
| Microorganism (Group I) | Human Disease (Group II) |
| P) Treponema pallidum | 4) Syphilis |
| Q) Trypanosoma cruzi | 3) Chagas disease |
| R) Trypanosoma gambiense | 1) Sleeping sickness |
| S) Bordetella pertussis | 2) Whooping cough |
Therefore, the correct answer is: P-4, Q-3, R-1, S-2.

Match the diseases in Group I with their causative organisms in Group II
Group I Group II
(P) Syphilis (1) Shigella dysenteriae
(Q) Bacillary dysentery (2) Bordetella pertussis
(R) Gas gangrene (3) Treponema pallidum
(S) Whooping cough (4) Clostridium perfringens