Question

Match the column I with column II. 
Column-I: (A) Autosomal trisomy, (B) Allosomal trisomy, (C) Allosomal Monosomy, (D) Cystic fibrosis 
Column-II: (i) Turner's Syndrome, (ii) Mendelian disorder, (iii) Klinefelter's Syndrome, (iv) Down's Syndrome
 

• A. (A)-(i); (B)-(ii); (C)-(iii); (D)-(iv)
• B. (A)-(i); (B)-(ii); (C)-(iv); (D)-(iii)
• C. (A)-(iv); (B)-(iii); (C)-(ii); (D)-(i)
• D. (A)-(iv); (B)-(iii); (C)-(i); (D)-(ii)

Hint:

Remember: "Autosomal" refers to chromosomes 1-22, while "Allosomal" refers to the X and Y chromosomes. "Monosomy" always implies 45 chromosomes, and "Trisomy" always implies 47.

Answer 1

The Correct Option is D

Step 1: Understanding the Concept:
Genetic disorders are classified as Chromosomal disorders (caused by changes in number or structure of chromosomes) or Mendelian disorders (caused by mutation in a single gene). Chromosomal disorders involve Aneuploidy, such as trisomy (extra chromosome) or monosomy (missing chromosome).
Step 2: Detailed Explanation:
1. Autosomal trisomy: This involves an extra copy of a non-sex chromosome. Down's Syndrome is trisomy of the 21st chromosome.
2. Allosomal trisomy: This involves an extra sex (allosome) chromosome. Klinefelter's Syndrome involves a genotype of XXY.
3. Allosomal Monosomy: This involves a missing sex chromosome. Turner's Syndrome involves a genotype of XO.
4. Mendelian disorder: These follow Mendelian inheritance patterns. Cystic fibrosis is an autosomal recessive Mendelian disorder.
Step 3: Final Answer
The correct matching sequence is (A)-(iv); (B)-(iii); (C)-(i); (D)-(ii).