Question

Kartagener's syndrome is NOT associated with

• A. Situs inversus
• B. Subluxation of lens
• C. Bronchiectasis
• D. Sinusitis

Hint:

Recall the classic triad of Kartagener's syndrome and check which option falls outside it.

Answer 1

The Correct Option is B

Step 1: Understanding the Question:
The question is testing the classic features of Kartagener's syndrome and asks which listed finding is NOT part of it.

Step 2: Key Concept or Approach:
Kartagener's syndrome is a subtype of primary ciliary dyskinesia caused by defective ciliary motility. Immotile or poorly motile cilia fail to clear mucus from the respiratory tract and fail to establish normal visceral laterality during development, which produces its classic triad.

Step 3: Working Through the Options:
Situs inversus occurs because ciliary motion in the embryo normally directs the leftward movement of organs; when cilia are immotile, organ placement becomes randomised, and roughly half of affected patients end up with situs inversus. Bronchiectasis results from chronic impaired mucociliary clearance in the lower airways, leading to recurrent infection and airway damage. Sinusitis follows the same mechanism in the paranasal sinuses, where stagnant mucus predisposes to chronic infection. Subluxation of the lens, however, is a feature of connective tissue and metabolic disorders such as Marfan's syndrome and homocystinuria, not of a ciliary motility defect, so it has no place in Kartagener's syndrome.

Step 4: Conclusion:
Kartagener's syndrome is NOT associated with subluxation of the lens.