Question

Increased LH : FSH ratio is found in

• A. Premature menopause
• B. Sheehan syndrome
• C. Polycystic ovary syndrome
• D. Turner's syndrome

Hint:

Ask which condition raises LH more than FSH, not the other way round.

Answer 1

The Correct Option is C

Step 1: Understanding the Question:
The question asks which condition classically shows a raised LH to FSH ratio, meaning LH runs higher than FSH on blood testing.

Step 2: Key Formula or Approach:
Normally LH and FSH stay close to each other before ovulation. An LH:FSH ratio above about 2:1, and sometimes 3:1, is the textbook clue for polycystic ovary syndrome (PCOS), because faster GnRH pulses from the hypothalamus push the pituitary to make more LH than FSH.

Step 3: Detailed Explanation:
In premature menopause and in Turner syndrome, the ovaries fail early or never develop properly. Because the ovaries make very little inhibin B, the pituitary loses its main brake on FSH, so FSH rises even more than LH. This gives a raised FSH:LH ratio, not a raised LH:FSH ratio.
In Sheehan syndrome, the pituitary itself gets damaged after severe post partum bleeding, so it makes less of everything, including LH and FSH. Both hormones fall, they do not rise.
In PCOS, the ovaries are intact but the GnRH pulse pattern favors LH release. This pushes LH up while FSH stays low to normal, producing the classic raised LH:FSH ratio used to support a PCOS diagnosis.

Step 4: Final Answer:
The source key on this paper marks option (D), Turner syndrome, but that condition raises FSH more than LH, giving a high FSH:LH ratio instead. The well established teaching point, a raised LH:FSH ratio, belongs to polycystic ovary syndrome, so the correct answer is option (C).