Concept:
Biology uses specific terms to describe increase in cell size, increase in cell number and enlargement of organs. These terms should not be confused with one another.
Step 1: Understand the meaning of Hypertrophy.
Hypertrophy means
\[
\text{Increase in size of existing cells}
\]
without increasing their number.
Step 2: Understand the meaning of Hyperplasia.
Hyperplasia means
\[
\text{Increase in number of cells}
\]
Therefore Hyperplasia does not refer to increase in cell size.
Step 3: Understand the meaning of Splenomegaly.
Splenomegaly means
\[
\text{Enlargement of spleen}
\]
and has no relation with increase in RBC size.
Step 4: Apply the definition to the question.
The question states that RBC size increases.
Increase in size of a cell is called
\[
\boxed{\text{Hypertrophy}}
\]
Step 5: Select the correct answer.
Hence,
\[
\boxed{\text{Option (B)}}
\]
is correct.