Question:
In which one of the following situations is Amniocentesis NOT called for?
In which one of the following situations is Amniocentesis NOT called for?
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Look for an actual raised risk marker in each option, a Rh negative status alone, with healthy prior children, does not by itself demand amniocentesis.
Updated On: Jul 7, 2026
- Mother's age is 35 years or more
- Parents who are known to have chromosomal translocation
- Raised alpha fetoprotein in amniotic fluid during an earlier pregnancy
- A Rh negative multipara mother aged 30 years with two live healthy boys
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Verified By Collegedunia
The Correct Option is D
Solution and Explanation
Step 1: Understanding the Question.
The question asks which situation is NOT an indication for doing amniocentesis, a test that samples amniotic fluid to check for fetal chromosomal or neural tube problems.
Step 2: Key Concept.
Amniocentesis is offered when there is a real, raised risk of a chromosomal abnormality or a structural defect in the current pregnancy, based on maternal age, family history, or a past pregnancy outcome.
Step 3: Detailed Explanation.
A mother aged 35 years or more has a clearly higher risk of a chromosomally abnormal fetus, such as Down syndrome, so amniocentesis is indicated here.
Parents known to carry a chromosomal translocation can pass on an unbalanced translocation to the fetus, so prenatal chromosomal testing through amniocentesis is indicated.
A raised alpha fetoprotein level in amniotic fluid during an earlier pregnancy points to a higher chance of a neural tube defect recurring, so amniocentesis is indicated in the current pregnancy to check for this again.
The last option describes a Rh negative multipara mother, aged only 30 years, who already has two live healthy boys. There is no mention of a rising anti-D antibody titre or any past baby affected by Rh hemolytic disease. Without evidence of maternal sensitization, this situation by itself is not an indication for amniocentesis. Routine anti-D immunoglobulin prophylaxis, not amniocentesis, is the standard step for a Rh negative mother who is not yet sensitized.
Step 4: Final Answer.
Amniocentesis is not called for in the case of a Rh negative multipara mother aged 30 years with two live healthy boys, since there is no sign of Rh sensitization needing evaluation.
The question asks which situation is NOT an indication for doing amniocentesis, a test that samples amniotic fluid to check for fetal chromosomal or neural tube problems.
Step 2: Key Concept.
Amniocentesis is offered when there is a real, raised risk of a chromosomal abnormality or a structural defect in the current pregnancy, based on maternal age, family history, or a past pregnancy outcome.
Step 3: Detailed Explanation.
A mother aged 35 years or more has a clearly higher risk of a chromosomally abnormal fetus, such as Down syndrome, so amniocentesis is indicated here.
Parents known to carry a chromosomal translocation can pass on an unbalanced translocation to the fetus, so prenatal chromosomal testing through amniocentesis is indicated.
A raised alpha fetoprotein level in amniotic fluid during an earlier pregnancy points to a higher chance of a neural tube defect recurring, so amniocentesis is indicated in the current pregnancy to check for this again.
The last option describes a Rh negative multipara mother, aged only 30 years, who already has two live healthy boys. There is no mention of a rising anti-D antibody titre or any past baby affected by Rh hemolytic disease. Without evidence of maternal sensitization, this situation by itself is not an indication for amniocentesis. Routine anti-D immunoglobulin prophylaxis, not amniocentesis, is the standard step for a Rh negative mother who is not yet sensitized.
Step 4: Final Answer.
Amniocentesis is not called for in the case of a Rh negative multipara mother aged 30 years with two live healthy boys, since there is no sign of Rh sensitization needing evaluation.
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