Question:
In a postmenopausal woman, the first-line drug for osteoporosis is:
In a postmenopausal woman, the first-line drug for osteoporosis is:
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The drug class that blocks osteoclasts is the standard first choice.
Updated On: Jun 23, 2026
- OCP
- Bisphosphonates
- Raloxifene
- Strontium
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The Correct Option is B
Solution and Explanation
Step 1: First-line therapy for postmenopausal osteoporosis is bisphosphonates.
Step 2: Alendronate, etidronate, pamidronate and ibandronate inhibit osteoclast-mediated bone resorption. They are effective for both prevention and treatment of osteoporosis, and are also used for Paget disease and osteolytic bone metastasis.
Step 3: Raloxifene is a selective estrogen receptor modulator and is useful, but it is a hormonal agent and not first-line. OCPs are not osteoporosis therapy. Strontium ranelate is a second-line option.
So bisphosphonates are the answer.
Step 2: Alendronate, etidronate, pamidronate and ibandronate inhibit osteoclast-mediated bone resorption. They are effective for both prevention and treatment of osteoporosis, and are also used for Paget disease and osteolytic bone metastasis.
Step 3: Raloxifene is a selective estrogen receptor modulator and is useful, but it is a hormonal agent and not first-line. OCPs are not osteoporosis therapy. Strontium ranelate is a second-line option.
So bisphosphonates are the answer.
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