Step 1: Take logarithm and differentiate.
Given,
\[
y=\left(x+\sqrt{x^{2}+1}\right)^5.
\]
Taking logarithm,
\[
\ln y
=
5\ln\!\left(x+\sqrt{x^{2}+1}\right).
\]
Since
\[
\frac{d}{dx}
\ln\!\left(x+\sqrt{x^{2}+1}\right)
=
\frac1{\sqrt{x^{2}+1}},
\]
we obtain
\[
\frac{y'}{y}
=
\frac5{\sqrt{x^{2}+1}}.
\]
Hence,
\[
y'
=
\frac{5y}{\sqrt{x^{2}+1}}.
\]
Step 2: Differentiate once again.
Differentiating,
\[
y''
=
\frac{5y'}{\sqrt{x^{2}+1}}
-
\frac{5xy}{(x^{2}+1)^{3/2}}.
\]
Substituting
\[
y'
=
\frac{5y}{\sqrt{x^{2}+1}},
\]
gives
\[
y''
=
\frac{25y}{x^{2}+1}
-
\frac{5xy}{(x^{2}+1)^{3/2}}.
\]
Multiplying throughout by
\[
x^{2}+1,
\]
\[
(x^{2}+1)y''
=
25y
-
\frac{5xy}{\sqrt{x^{2}+1}}.
\]
Using
\[
y'
=
\frac{5y}{\sqrt{x^{2}+1}},
\]
we get
\[
\boxed{
25y
=
(x^{2}+1)y''
+
xy'.
}
\]
Using the notation
\[
y_1=y',
\qquad
y_2=y'',
\]
we obtain
\[
\boxed{
25y=(x^{2}+1)y_{2}+xy_{1}.
}
\]
Hence, the correct option is \(\boxed{(B)}\).