For isotropic materials, Young's modulus \( E \), shear modulus \( G \), and Poisson's ratio \( \nu \) are related by
\[
E = 2G(1 + \nu).
\]
The Poisson's ratio for isotropic materials lies within
\[
-1 < \nu < \tfrac{1}{2}.
\]
Thus, the maximum value occurs at \( \nu = \tfrac{1}{2} \), giving
\[
E_{\max} = 2G \left( 1 + \tfrac{1}{2} \right) = 3G.
\]
So the largest physically possible Young's modulus for an isotropic material is \( 3G \).
Final Answer: \( 3G \)