Question

How does the parasite damage the human body after entering the blood stream?

Hint:

Hemozoin is the "malaria pigment" formed from the digestion of host hemoglobin. It is the specific chemical cause of the fever.

Answer 1

Step 1: Understanding the Concept:
After an initial phase in the liver, the parasite enters the erythrocytic (RBC) cycle, which is responsible for the clinical symptoms of malaria.
Step 2: Detailed Explanation:
1. After escaping the liver, the parasites (merozoites) attack the Red Blood Cells (RBCs).
2. They multiply asexually inside the RBCs.
3. The parasites eventually cause the RBCs to rupture.
4. Upon rupture, a toxic substance called hemozoin is released into the blood.
5. Hemozoin is responsible for the characteristic chills and high fever recurring every 3 to 4 days.
Step 3: Final Answer:
The parasite ruptures RBCs and releases hemozoin, causing recurring high fever and body-wide stress.