We are given the function $z(x, y) = e^{x - 2y}$. To find the total differential $\frac{dz}{dt}$, we use the chain rule. First, we calculate the partial derivatives of $z$ with respect to $x$ and $y$:
\[
\frac{\partial z}{\partial x} = e^{x - 2y}, \frac{\partial z}{\partial y} = -2e^{x - 2y}
\]
Now, apply the chain rule:
\[
\frac{dz}{dt} = \frac{\partial z}{\partial x} \frac{dx}{dt} + \frac{\partial z}{\partial y} \frac{dy}{dt}
\]
Substitute the values of $\frac{dx}{dt} = e^t$ and $\frac{dy}{dt} = -e^{-t}$ into the equation:
\[
\frac{dz}{dt} = e^{x - 2y} \cdot e^t + (-2e^{x - 2y}) \cdot (-e^{-t}) = e^{x - 2y}(e^t + 2e^{-t})
\]
Thus, the total differential is:
\[
\frac{dz}{dt} = z(x + 2y)
\]
Therefore, the correct answer is (C).