Concept:
The cardinal ligament is one of the most important supports of the uterus. Weakness of pelvic supports, especially after childbirth, can lead to uterine prolapse.
Step 1: Identify the condition.
Uterine prolapse means downward displacement of the uterus due to weakness of its supports.
Step 2: Recall major uterine supports.
Important supports of the uterus include:
\[
\text{Cardinal ligament + uterosacral ligament + pelvic floor muscles}
\]
Among these, the cardinal ligament provides major transverse support to the cervix and uterus.
Step 3: Choose the most important weak structure.
In uterine prolapse, weakness of the cardinal ligament is a key factor.
Therefore, the correct answer is Cardinal ligament.