Question:
Four months after a renal transplant, a patient is most likely to develop infection with which of the following organisms?
Four months after a renal transplant, a patient is most likely to develop infection with which of the following organisms?
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Which virus reactivates and peaks in the 1 to 6 month window after solid-organ transplant?
Updated On: Jun 23, 2026
- Epstein-Barr virus (EBV)
- Cytomegalovirus (CMV)
- Candida
- Histoplasma
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The Correct Option is B
Solution and Explanation
Correct option: CMV.
Step 1: Post-transplant infections follow a time-line. The intermediate period (roughly 1 to 6 months) after transplant is dominated by opportunistic and reactivating viral infections because immunosuppression is at its peak.
Step 2: CMV is the single most important and most common opportunistic pathogen in this 1 to 6 month window. It causes graft dysfunction, fever, leucopenia, pneumonitis and colitis, and is a recognised cause of allograft dysfunction.
Why the others are less likely: Candida is mainly an early (first month) nosocomial/surgical-site issue. EBV-driven post-transplant lymphoproliferative disease and fungal infections such as Histoplasma tend to surface later or are far less common at exactly 4 months.
Ref: Bailey and Love, Short Practice of Surgery, 27th edition, 2018.
Step 1: Post-transplant infections follow a time-line. The intermediate period (roughly 1 to 6 months) after transplant is dominated by opportunistic and reactivating viral infections because immunosuppression is at its peak.
Step 2: CMV is the single most important and most common opportunistic pathogen in this 1 to 6 month window. It causes graft dysfunction, fever, leucopenia, pneumonitis and colitis, and is a recognised cause of allograft dysfunction.
Why the others are less likely: Candida is mainly an early (first month) nosocomial/surgical-site issue. EBV-driven post-transplant lymphoproliferative disease and fungal infections such as Histoplasma tend to surface later or are far less common at exactly 4 months.
Ref: Bailey and Love, Short Practice of Surgery, 27th edition, 2018.
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