Step 1: Total arrangements without restriction.
Word: INDEPENDENCE (12 letters).
Letter frequencies: I – 1, N – 3, D – 2, E – 4, P – 1, C – 1.
Total arrangements:
\[
\frac{12!}{3! \cdot 2! \cdot 4!} = \frac{479001600}{288} = 1663200
\]
Step 2: Count arrangements with all 4 E’s together.
Treat 4 E’s as one block. Then total symbols = \(12 - 4 + 1 = 9\).
Frequencies now: N – 3, D – 2, (E-block) – 1, I – 1, P – 1, C – 1.
Total =
\[
\frac{9!}{3! \cdot 2!} = \frac{362880}{12} = 30240
\]
Step 3: Subtract.
Words with E’s not together = \(1663200 - 30240 = 1632960\).
Final Answer:
\[
\boxed{1632960}
\]