To find the derivative of the given function, we will apply the power rule for differentiation, which states that for \( y = ax^n \), the derivative is \( \frac{dy}{dx} = n \cdot ax^{n-1} \).
Given:
\[
y = x^6 + 48x^3 + 24x - 16
\]
We will differentiate each term of the function with respect to \( x \).
\[
\frac{dy}{dx} = \frac{d}{dx}(x^6) + \frac{d}{dx}(48x^3) + \frac{d}{dx}(24x) - \frac{d}{dx}(16)
\]
Step 1: Differentiating each term.
1. The derivative of \( x^6 \) is:
\[
\frac{d}{dx}(x^6) = 6x^5
\]
2. The derivative of \( 48x^3 \) is:
\[
\frac{d}{dx}(48x^3) = 3 \times 48x^2 = 144x^2
\]
3. The derivative of \( 24x \) is:
\[
\frac{d}{dx}(24x) = 24
\]
4. The derivative of \( -16 \) is:
\[
\frac{d}{dx}(-16) = 0
\]
Step 2: Combine the derivatives.
Now, combine all the derivatives:
\[
\frac{dy}{dx} = 6x^5 + 144x^2 + 24
\]
Thus, the derivative of \( y \) with respect to \( x \) is:
\[
\boxed{\frac{dy}{dx} = 6x^5 + 144x^2 + 24}
\]