We are tasked with evaluating the integral:
\[
I = \int 16x^3 \log_e x \, dx
\]
Step 1: Use integration by parts.
To solve this, we use the integration by parts formula:
\[
\int u \, dv = uv - \int v \, du
\]
Let:
\[
u = \log_e x \quad \text{and} \quad dv = 16x^3 dx
\]
Then:
\[
du = \frac{1}{x} dx \quad \text{and} \quad v = \int 16x^3 dx = 4x^4
\]
Step 2: Apply the integration by parts formula.
Now, apply the formula:
\[
I = uv - \int v \, du
\]
Substitute the values of \( u \), \( v \), \( du \), and \( dv \):
\[
I = \log_e x \cdot 4x^4 - \int 4x^4 \cdot \frac{1}{x} dx
\]
Simplify the second integral:
\[
I = 4x^4 \ln x - \int 4x^3 dx
\]
Now, integrate \( \int 4x^3 dx \):
\[
I = 4x^4 \ln x - 4 \times \frac{x^4}{4}
\]
\[
I = 4x^4 \ln x - x^4
\]
Thus, the value of the integral is:
\[
\boxed{16x^4 \ln x - 4x^4}
\]