Step 1: Use substitution.
Let
\[
u=4-x^{2}.
\]
Then,
\[
du=-2x\,dx,
\]
or
\[
x\,dx=-\frac12\,du.
\]
Also,
\[
x^{2}=4-u.
\]
Hence,
\[
x^{3}dx
=
x^{2}(x\,dx)
=
-\frac12(4-u)\,du.
\]
The limits become
\[
x=0\Rightarrow u=4,
\]
\[
x=2\Rightarrow u=0.
\]
Therefore,
\[
I
=
\frac12
\int_{0}^{4}(4-u)u^{5/2}\,du.
\]
Step 2: Expand and integrate.
\[
I
=
\frac12
\left[
4\int_{0}^{4}u^{5/2}\,du
-
\int_{0}^{4}u^{7/2}\,du
\right].
\]
Using
\[
\int u^{5/2}du=\frac{2}{7}u^{7/2},
\]
and
\[
\int u^{7/2}du=\frac{2}{9}u^{9/2},
\]
we obtain
\[
I
=
\frac12
\left[
\frac87u^{7/2}
-
\frac29u^{9/2}
\right]_{0}^{4}.
\]
Step 3: Substitute the limits.
Since
\[
4^{7/2}=128,
\qquad
4^{9/2}=512,
\]
we get
\[
I
=
\frac12
\left(
\frac{1024}{7}
-
\frac{1024}{9}
\right).
\]
\[
=
\frac12
\cdot
1024
\left(
\frac{2}{63}
\right)
=
\frac{1024}{63}.
\]
Hence,
\[
\boxed{
\int_{0}^{2}x^{3}(4-x^{2})^{5/2}\,dx
=
\frac{1024}{63}.
}
\]
Therefore, the correct option is \(\boxed{(D)}\).