Step 1: The standard 12-lead ECG views the heart mainly from the anterior, lateral and inferior directions, with no lead looking directly at the posterior (and to a large extent the lateral) wall of the left ventricle.
Step 2: The left circumflex (LCx) artery supplies the posterolateral wall of the left ventricle, a territory that is electrically “silent” on the routine 12-lead recording.
Step 3: Because no standard lead faces this region, ischaemia or infarction in the LCx territory often produces only subtle or absent ST-T changes and is the most frequently missed on ECG.
Step 4: In contrast, the left anterior descending artery shows up in the precordial/anterior leads, and the right coronary artery shows up in the inferior leads, so their territories are well represented.
Conclusion: The ECG is poorest at detecting ischaemia in the left circumflex territory, so option 2 is correct.