Question:
Dyslipidaemia with raised triglyceride and low HDL cholesterol is seen in all of the following EXCEPT
Dyslipidaemia with raised triglyceride and low HDL cholesterol is seen in all of the following EXCEPT
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Think about which of these actually raises HDL rather than lowering it.
Updated On: Jul 7, 2026
- Uncontrolled diabetes mellitus
- Hypertensive on Beta blocker Therapy
- Regular alcohol consumption
- Obesity with BMI more than 30
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The Correct Option is C
Solution and Explanation
Step 1: Understanding the Question:
We need to find which of the four situations does NOT show the pattern of raised triglyceride together with low HDL cholesterol.
Step 2: Key Formula or Approach:
This lipid pattern, high triglyceride with low HDL, is the hallmark of insulin resistance and the metabolic syndrome. Anything that worsens insulin resistance or directly interferes with HDL production will produce it. Anything that raises HDL, even if it also raises triglyceride, will not fit the pattern completely.
Step 3: Detailed Explanation:
Uncontrolled diabetes mellitus causes insulin resistance and lack of insulin action on lipoprotein lipase, so VLDL and triglyceride rise while HDL falls. This is the classic diabetic dyslipidemia and fits the pattern.
Non-selective beta blockers without intrinsic sympathomimetic activity are well known to raise triglyceride and lower HDL cholesterol as a side effect of therapy. So a hypertensive patient on beta blockers also fits the pattern.
Obesity with a BMI over 30 is linked with insulin resistance, increased free fatty acid flow to the liver and higher VLDL output, along with low HDL. This too fits the pattern.
Regular alcohol consumption is different. Moderate, regular alcohol intake is known to raise HDL cholesterol, mainly by increasing production of Apo A1. While heavy drinking can raise triglyceride, the HDL is typically raised, not lowered, so alcohol does not give the combination of high triglyceride with low HDL.
Step 4: Final Answer:
Regular alcohol consumption is the exception, since it tends to raise HDL cholesterol rather than lower it, unlike diabetes, beta blocker therapy and obesity, all of which lower HDL.
We need to find which of the four situations does NOT show the pattern of raised triglyceride together with low HDL cholesterol.
Step 2: Key Formula or Approach:
This lipid pattern, high triglyceride with low HDL, is the hallmark of insulin resistance and the metabolic syndrome. Anything that worsens insulin resistance or directly interferes with HDL production will produce it. Anything that raises HDL, even if it also raises triglyceride, will not fit the pattern completely.
Step 3: Detailed Explanation:
Uncontrolled diabetes mellitus causes insulin resistance and lack of insulin action on lipoprotein lipase, so VLDL and triglyceride rise while HDL falls. This is the classic diabetic dyslipidemia and fits the pattern.
Non-selective beta blockers without intrinsic sympathomimetic activity are well known to raise triglyceride and lower HDL cholesterol as a side effect of therapy. So a hypertensive patient on beta blockers also fits the pattern.
Obesity with a BMI over 30 is linked with insulin resistance, increased free fatty acid flow to the liver and higher VLDL output, along with low HDL. This too fits the pattern.
Regular alcohol consumption is different. Moderate, regular alcohol intake is known to raise HDL cholesterol, mainly by increasing production of Apo A1. While heavy drinking can raise triglyceride, the HDL is typically raised, not lowered, so alcohol does not give the combination of high triglyceride with low HDL.
Step 4: Final Answer:
Regular alcohol consumption is the exception, since it tends to raise HDL cholesterol rather than lower it, unlike diabetes, beta blocker therapy and obesity, all of which lower HDL.
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