Question:
Duct most commonly involved in chronic pancreatitis is:
Duct most commonly involved in chronic pancreatitis is:
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The primary drainage duct of the pancreas shows characteristic chain-of-lakes dilatation in this condition.
Updated On: Jun 23, 2026
- Main pancreatic duct (Wirsung)
- Accessory pancreatic duct (Santorini)
- Common bile duct
- Ampulla of Vater
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The Correct Option is A
Solution and Explanation
Step 1: Pathology of chronic pancreatitis.
Chronic pancreatitis is a progressive inflammatory condition of the pancreas characterized by irreversible parenchymal fibrosis, loss of exocrine and endocrine function, and ductal changes.
Step 2: Ductal involvement in chronic pancreatitis.
The main pancreatic duct (duct of Wirsung) is the primary drainage duct of the pancreas and is the duct most commonly involved in chronic pancreatitis. Characteristic changes include:
The involvement of the main pancreatic duct (Wirsung) is the basis for surgical drainage procedures such as the Puestow procedure (lateral pancreaticojejunostomy), which decompresses the obstructed main duct to relieve pain.
Conclusion: The main pancreatic duct (duct of Wirsung) is the duct most commonly involved in chronic pancreatitis.
Chronic pancreatitis is a progressive inflammatory condition of the pancreas characterized by irreversible parenchymal fibrosis, loss of exocrine and endocrine function, and ductal changes.
Step 2: Ductal involvement in chronic pancreatitis.
The main pancreatic duct (duct of Wirsung) is the primary drainage duct of the pancreas and is the duct most commonly involved in chronic pancreatitis. Characteristic changes include:
- Irregular dilatation and stricturing of the main pancreatic duct (chain-of-lakes appearance on MRCP or ERCP)
- Intraductal calculi (stones)
- Ductal hypertension leading to pain
The involvement of the main pancreatic duct (Wirsung) is the basis for surgical drainage procedures such as the Puestow procedure (lateral pancreaticojejunostomy), which decompresses the obstructed main duct to relieve pain.
Conclusion: The main pancreatic duct (duct of Wirsung) is the duct most commonly involved in chronic pancreatitis.
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