Question:
Cyclic AMP (cAMP) acts as a second messenger for which of the following primary signaling molecule(s)?
Cyclic AMP (cAMP) acts as a second messenger for which of the following primary signaling molecule(s)?
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cAMP = G-protein coupled receptor → Adenylyl cyclase → PKA activation.
Used by epinephrine and glucagon signaling.
Updated On: Dec 5, 2025
- Retinoic acid
- Prostaglandins
- Cortisol
- Epinephrine
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The Correct Option is B, D
Solution and Explanation
Step 1: Recall cAMP pathway.
cAMP (cyclic adenosine monophosphate) is synthesized from ATP by adenylyl cyclase upon activation of G-protein-coupled receptors (GPCRs).
Step 2: Identify signaling molecules using cAMP.
Hormones such as epinephrine, glucagon, and ACTH use cAMP as a second messenger to activate protein kinase A (PKA).
Step 3: Eliminate incorrect options.
(A) Retinoic acid and (C) Cortisol act via intracellular receptors (nuclear).
(B) Prostaglandins often use IP$_3$/DAG as second messengers.
Step 4: Conclusion.
Hence, cAMP acts as a second messenger for epinephrine.
cAMP (cyclic adenosine monophosphate) is synthesized from ATP by adenylyl cyclase upon activation of G-protein-coupled receptors (GPCRs).
Step 2: Identify signaling molecules using cAMP.
Hormones such as epinephrine, glucagon, and ACTH use cAMP as a second messenger to activate protein kinase A (PKA).
Step 3: Eliminate incorrect options.
(A) Retinoic acid and (C) Cortisol act via intracellular receptors (nuclear).
(B) Prostaglandins often use IP$_3$/DAG as second messengers.
Step 4: Conclusion.
Hence, cAMP acts as a second messenger for epinephrine.
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