Question:

Clue cells are seen in:

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Epithelial cells studded with Gardnerella coccobacilli.
Updated On: Jun 24, 2026
  • Bacterial vaginosis
  • Vaginal candidiasis
  • Chlamydial vaginosis
  • Trichomoniasis
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The Correct Option is A

Solution and Explanation

Step 1: Define clue cells. Clue cells are vaginal epithelial squamous cells whose borders are obscured (stippled and granular) by adherent coccobacilli, mainly Gardnerella vaginalis.
Step 2: Link them to the disease. Clue cells are a key Amsel criterion for bacterial vaginosis, along with a thin homogeneous discharge, vaginal pH above 4.5 and a positive whiff (amine) test.
Step 3: Exclude the alternatives. Vaginal candidiasis shows budding yeast and pseudohyphae with a thick curdy discharge. Chlamydial infection is diagnosed by NAAT, not clue cells. Trichomoniasis shows motile flagellated trophozoites on wet mount with a frothy discharge.
Step 4: Conclusion. Clue cells are characteristic of bacterial vaginosis.
The medically correct and printed answer is option 1.
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