Step 1: Word meaning.
The word "Despise" means to feel contempt or a strong dislike for someone or something.
Step 2: Spellings check.
(A) Dispuse: Incorrect.
(B) Dispise: Incorrect vowel placement.
(C) Despise: Correct spelling.
(D) Duspuse: Incorrect.
Step 3: Conclusion.
Correct spelling is (C) Despise.