Question

Carbapenem which has tendency to cause maximum seizures?

• A. Imipenem
• B. Ertapenem
• C. Doripenem
• D. Meropenem

Answer 1

The Correct Option is A

Pharmacological Explanation

Carbapenems are a class of beta-lactam antibiotics known for their broad spectrum of activity and resistance to most beta-lactamases.

Analysis of Seizure Risk

The tendency of carbapenems to cause seizures is linked to their penetration through the blood-brain barrier and interaction with the central nervous system.

Among the options:

• Imipenem: This drug has been most commonly associated with seizures, especially in patients with renal impairment or those with predisposing factors such as neurological disease.
• Ertapenem, Doripenem, Meropenem: These have a lower incidence of seizures compared to Imipenem as they are either less rapidly cleared by the kidneys or have less CNS penetration.

Conclusion

Based on the above pharmacological characteristics and clinical evidence, Imipenem is identified as the carbapenem with the highest risk of inducing seizures.