Question:

Breathing difficulty with generalized weakness. On auscultation a mid diastolic murmur with prominent wave is seen in:

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A prominent 'a' wave in the JVP combined with a mid-diastolic murmur indicates obstruction at the right AV valve.
Updated On: Jun 23, 2026
  • TS (Tricuspid Stenosis)
  • MS (Mitral Stenosis)
  • MR (Mitral Regurgitation)
  • TR (Tricuspid Regurgitation)
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The Correct Option is A

Solution and Explanation

Step 1: Analyze the murmur character.
Mid-diastolic murmur = obstruction to flow across an AV valve during ventricular filling (diastole). The two valves that can produce a mid-diastolic murmur are the mitral valve (MS) and the tricuspid valve (TS).

Step 2: Identify the prominent wave clue.
In tricuspid stenosis, right atrial pressure is elevated and the JVP shows a prominent 'a' wave (due to forceful right atrial contraction against a stenosed tricuspid valve). This is a hallmark of TS.

Step 3: Differentiate TS from MS.
  • Mitral stenosis (MS): mid-diastolic murmur at apex, opening snap, loud S1; associated with left atrial enlargement.
  • Tricuspid stenosis (TS): mid-diastolic murmur at left lower sternal border, increases on inspiration (Carvallo's sign), prominent 'a' wave in JVP, hepatomegaly, right heart failure features.

The clinical picture of generalized weakness + breathing difficulty + mid-diastolic murmur + prominent wave (a-wave in JVP) is consistent with Tricuspid Stenosis.

Almost all TS cases result from rheumatic fever. Symptoms include fatigue, cold peripheries, and right upper quadrant discomfort from hepatomegaly.
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