Question:
Bence Jones proteins are derived from:
Bence Jones proteins are derived from:
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Bence Jones protein is an immunoglobulin light chain, and antibodies run in one band.
Updated On: Jun 24, 2026
- Alpha globulins
- Beta globulins
- Gamma globulins
- Delta globulins
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The Correct Option is C
Solution and Explanation
Step 1: Recall the nature of Bence Jones protein. It consists of free monoclonal immunoglobulin light chains (kappa or lambda) found in urine, classically in multiple myeloma.
Step 2: Place immunoglobulins on serum electrophoresis. Immunoglobulins (antibodies) migrate in the gamma globulin region of the serum protein electrophoresis strip. The monoclonal spike of myeloma is the M band in the gamma zone.
Step 3: Connect the two facts. Since Bence Jones protein is an immunoglobulin light chain fragment, it is derived from the gamma globulin fraction.
Step 4: Reject the others. Alpha and beta globulins carry transport and acute phase proteins (alpha-1 antitrypsin, haptoglobin, transferrin and so on), not immunoglobulins. There is no recognised delta globulin band on standard electrophoresis.
Step 5: Hence Bence Jones protein is a gamma globulin derivative.
Answer: C. Gamma globulins.
Step 2: Place immunoglobulins on serum electrophoresis. Immunoglobulins (antibodies) migrate in the gamma globulin region of the serum protein electrophoresis strip. The monoclonal spike of myeloma is the M band in the gamma zone.
Step 3: Connect the two facts. Since Bence Jones protein is an immunoglobulin light chain fragment, it is derived from the gamma globulin fraction.
Step 4: Reject the others. Alpha and beta globulins carry transport and acute phase proteins (alpha-1 antitrypsin, haptoglobin, transferrin and so on), not immunoglobulins. There is no recognised delta globulin band on standard electrophoresis.
Step 5: Hence Bence Jones protein is a gamma globulin derivative.
Answer: C. Gamma globulins.
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