Question:
Antiphospholipid antibody (APLA) syndrome is associated with all of the following except:
Antiphospholipid antibody (APLA) syndrome is associated with all of the following except:
Show Hint
APLA syndrome causes clotting, not bleeding, despite the lupus anticoagulant name.
Updated On: Jun 24, 2026
- Bleeding disorders
- Thrombotic disorders
- Coagulation disorders
- Recurrent fetal loss
Show Solution
Verified By Collegedunia
The Correct Option is A
Solution and Explanation
Step 1: Antiphospholipid antibody syndrome is an autoimmune state with antibodies such as lupus anticoagulant, anticardiolipin, and anti beta-2 glycoprotein I. The defining problem is a tendency to clot, not to bleed.
Step 2: The hallmark is thrombosis, both venous (deep vein thrombosis, pulmonary embolism) and arterial (stroke). So option B is a true association.
Step 3: Because the antibodies disturb clotting tests, the syndrome is linked to abnormal coagulation findings, classically a prolonged aPTT that does not correct on mixing, so option C is also a true association.
Step 4: Placental thrombosis causes recurrent pregnancy loss, a core obstetric criterion of the syndrome, so option D is true.
Step 5: APLA is a pro-thrombotic, not a bleeding, disorder. The misnomer 'lupus anticoagulant' only refers to in vitro test prolongation, not in vivo bleeding. So option A is the exception.
Correct option: A.
Step 2: The hallmark is thrombosis, both venous (deep vein thrombosis, pulmonary embolism) and arterial (stroke). So option B is a true association.
Step 3: Because the antibodies disturb clotting tests, the syndrome is linked to abnormal coagulation findings, classically a prolonged aPTT that does not correct on mixing, so option C is also a true association.
Step 4: Placental thrombosis causes recurrent pregnancy loss, a core obstetric criterion of the syndrome, so option D is true.
Step 5: APLA is a pro-thrombotic, not a bleeding, disorder. The misnomer 'lupus anticoagulant' only refers to in vitro test prolongation, not in vivo bleeding. So option A is the exception.
Correct option: A.
Was this answer helpful?
0
0
Top NEET PG Medicine Questions
- Identify the condition associated with the murmur in the image below
- A young man came to the medical OPD with complaints of early morning backache and stiffness, which improves on exercise, and persistent red eyes. On examination, lung expansion was less than 3 cm. X-ray is shown in the image given below.
What is the most probable diagnosis? - A patient with hyperkalemia and elevated urea levels underwent dialysis. Towards the end of the session, she became drowsy and had a sudden seizure episode. On examination, thepatient was hypotensive. What is the treatment for this condition?
- A female patient presents to the emergency department with severe restlessness, palpitations, and tremors. She is a known case of bronchial asthma. On examination, the neck looksswollen. Blood pressure is elevated, and tachycardia is noted. ECG shows atrial fibrillation.Which of the following drugs is used for immediate management in this patient?
- A 30-year-old male is found to be positive for HBsAg and HBeAg and is diagnosed with chronic hepatitis B. The patient’s viral load was 2x 100000 and SGPT is found to be doubled. What is the appropriate management in this patient? SGPT-Serum glutamate pyruvate transaminase
View More Questions
Top NEET PG Antiphospholipid antibody syndrome diagnosis Questions
- Which among the following is used for the diagnosis of antiphospholipid antibody syndrome?
- Which of the following is recommended in a woman with antiphospholipid antibodies and a history of prior abortions or still birth?
- All of the following statements about antiphospholipid antibody syndrome (APLA) are true except:
Top NEET PG Questions
- A patient hailing from Delhi presents with fever, arthralgia, and extensive petechial rash for 3 days. Lab investigations revealed a hemoglobin of 9 g/ dL, a white blood cell count of 9000 cells/mm3, a platelet count of 20000 cells/mm3, and a prolonged bleeding time. The clotting time was normal. What is the most likely diagnosis?
- Which of the following statements is true about Trichomonas vaginalis?
- A lady from West Rajasthan presented with an ulcer surrounded by erythema on the right leg. Microscopy of the biopsy from the edge of the ulcer showed organisms with dark staining nuclei and kinetoplast. What is the most likely causative agent?
- A child presents with a fever and a rash. Urine examination showed cells with owl's eye appearance. What is the most likely diagnosis?
- Infection with Clonorchis sinensis is associated with an increased risk of__?
View More Questions