Question

Among the following, the compounds which can be prepared by nucleophilic substitution reaction are: 

• A. III, IV, and V
• B. I, II, and VI
• C. II, IV, and VI
• D. I, III, and V

Hint:

In nucleophilic substitution reactions, a good leaving group (e.g., halides, acetates, nitro) is essential for the reaction to occur efficiently.

Answer 1

The Correct Option is C

In nucleophilic substitution reactions, the nucleophile attacks the electrophilic carbon, replacing a leaving group.

Step 1: Analyze the Compounds.
- (I) The azide ion (\( \text{N}_3^- \)) is a good nucleophile, but the structure shown does not indicate a typical leaving group or favorable conditions for substitution.
- (II) The acetoxy group (\( \text{OAc} \)) is a good leaving group, making this compound suitable for nucleophilic substitution.
- (III) The bromine group (\( \text{Br} \)) is a good leaving group, but the structure indicates a less favorable position for nucleophilic attack.
- (IV) The nitro group (\( \text{NO}_2 \)) on a benzene ring makes this compound reactive to nucleophilic substitution, especially under appropriate conditions.
- (V) The iodine group (\( \text{I} \)) is a good leaving group and allows nucleophilic substitution.
- (VI) The methoxy group (\( \text{OMe} \)) can undergo nucleophilic substitution, especially in suitable solvents.

Step 2: Conclusion.
The compounds that can undergo nucleophilic substitution are II, IV, and VI.

Final Answer: \[ II, IV, \text{ and } VI. \]